Comparison of brain natriuretic peptide and left ventricular diastolic function determined by tissue Doppler in patients with diabetes mellitus, patients with hypertension without diabetes, and in healthy subjects

Hoong Sern Lim; Jeetesh V Patel; Sunil Nadar; Elizabeth A Hughes; Gregory Y H Lip

doi:10.1016/j.amjcard.2004.12.024

Comparison of brain natriuretic peptide and left ventricular diastolic function determined by tissue Doppler in patients with diabetes mellitus, patients with hypertension without diabetes, and in healthy subjects

Am J Cardiol. 2005 Apr 1;95(7):905-8. doi: 10.1016/j.amjcard.2004.12.024.

Authors

Hoong Sern Lim¹, Jeetesh V Patel, Sunil Nadar, Elizabeth A Hughes, Gregory Y H Lip

Affiliation

¹ Haemostasis Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, United Kingdom.

PMID: 15781031
DOI: 10.1016/j.amjcard.2004.12.024

Abstract

In this study, it was found that increased plasma B-type natriuretic peptide (BNP) levels in patients with diabetes may be related to left ventricular (LV) diastolic relaxation, independent of LV mass and atherosclerosis (using common carotid intima-media thickness as a surrogate index). A "package of care" of glycemic control and cardiovascular risk management was not associated with reduction in BNP levels.

Publication types

Comparative Study

MeSH terms

Aged
Diabetes Complications*
Diastole
Echocardiography, Doppler
Female
Humans
Hypertension / complications*
Male
Middle Aged
Natriuretic Peptide, Brain / blood*
Ventricular Dysfunction, Left / blood*
Ventricular Dysfunction, Left / diagnostic imaging*
Ventricular Dysfunction, Left / etiology
Ventricular Dysfunction, Left / physiopathology

Substances

Natriuretic Peptide, Brain