Abstract
Seizures may occur after orthotopic liver transplantation. Antiepileptic drugs (AEDs) are used to treat these seizures, but the immunosuppressant regimen also may be altered. Levetiracetam is an attractive treatment because of its efficacy, lack of hepatic enzyme induction, and its rapid attainment of serum levels. Treatment with levetiracetam is efficacious, and levetiracetam-treated patients require significantly lower doses of immunosuppressant medications to achieve an equivalent antirejection effect.
Publication types
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Clinical Trial
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Research Support, Non-U.S. Gov't
MeSH terms
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Anticonvulsants / administration & dosage*
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Anticonvulsants / metabolism
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Cytochrome P-450 Enzyme System / drug effects
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Cytochrome P-450 Enzyme System / metabolism
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Dose-Response Relationship, Drug
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Drug Interactions / physiology
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Female
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Humans
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Immunosuppressive Agents / administration & dosage
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Immunosuppressive Agents / adverse effects*
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Immunosuppressive Agents / blood
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Levetiracetam
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Liver / drug effects
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Liver / immunology
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Liver / metabolism
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Liver Transplantation / adverse effects*
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Male
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Phenytoin / adverse effects
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Piracetam / administration & dosage
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Piracetam / analogs & derivatives*
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Piracetam / metabolism
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Postoperative Complications / chemically induced
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Postoperative Complications / drug therapy*
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Postoperative Complications / prevention & control
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Retrospective Studies
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Seizures / chemically induced
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Seizures / drug therapy*
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Seizures / prevention & control
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Treatment Outcome
Substances
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Anticonvulsants
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Immunosuppressive Agents
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Levetiracetam
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Phenytoin
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Cytochrome P-450 Enzyme System
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Piracetam