Hemiparkinsonism and levodopa-induced dyskinesias after focal nigral lesion

Mov Disord. 2005 Jun;20(6):759-62. doi: 10.1002/mds.20453.

Abstract

We present a patient with tremor-dominant hemiparkinsonism after a focal lesion to the substantia nigra. An excellent response to levodopa was complicated by rapid development of motor fluctuations and disabling dyskinesias. Stereotactic thalamotomy resulted in a persistent extinction of parkinsonism and of dyskinesias along with stopping dopaminergic treatment.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Antiparkinson Agents / adverse effects*
  • Dyskinesia, Drug-Induced / etiology*
  • Dyskinesia, Drug-Induced / pathology*
  • Female
  • Humans
  • Levodopa / adverse effects*
  • Magnetic Resonance Imaging / methods
  • Parkinsonian Disorders / complications
  • Parkinsonian Disorders / drug therapy
  • Substantia Nigra / drug effects*
  • Substantia Nigra / injuries
  • Substantia Nigra / pathology*

Substances

  • Antiparkinson Agents
  • Levodopa