Abstract
Ring-stage parasitized erythrocytes (RPEs) were demonstrated to interact with effector cells of the innate immune system. With receptor blockade studies and CD36-null macrophages, human and murine macrophages were shown to phagocytose RPEs through the pattern recognition receptor CD36. These in vitro data implicate scavenger receptors in the clearance of RPEs.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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CD36 Antigens / physiology*
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Erythrocytes / parasitology*
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Humans
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Immunity, Innate
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Macrophages / immunology
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Mice
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Mice, Inbred BALB C
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Phagocytosis*
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Plasmodium falciparum / immunology*
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Protozoan Proteins / physiology
Substances
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CD36 Antigens
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Protozoan Proteins
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erythrocyte membrane protein 1, Plasmodium falciparum