Abstract
[structure: see text] Chemical investigation of two field collections of marine cyanobacteria has led to the discovery of two new cytotoxic natural products, ankaraholides A (2) and B (3), along with the known compound swinholide A (1). Since swinholide-type compounds were previously localized to the heterotrophic bacteria of sponges, these findings raise intriguing questions about their true metabolic source.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification*
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Antineoplastic Agents / pharmacology
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Cyanobacteria / chemistry*
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Fiji
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Glycosylation
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Marine Toxins / chemistry
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Marine Toxins / isolation & purification*
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Marine Toxins / pharmacology
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Molecular Structure
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Porifera / chemistry*
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Pyrans / chemistry
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Pyrans / isolation & purification*
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Pyrans / pharmacology
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Symbiosis
Substances
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Antineoplastic Agents
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Marine Toxins
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Pyrans
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ankaraholide A
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ankaraholide B
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swinholide A