Abstract
We report a case on hemodialysis with metastatic rectal cancer who was introduced to CPT-11. Although the expected pharmacokinetics was shown 24 hours post-dialysis with the infusion of dose-reduced CPT-11, grade 4 neutropenia was observed. Considering the chronic renal failure status with latent lower function of multiple organs, the dose escalation method was recommended while watching the pharmacokinetics. CPT-11 is not only the key compound for metastatic colorectal cancer, but is also effective with several other cancers. It is important for cancer patients with chronic renal failure that the feasibility and efficacy of CPT-11 should be determined by future study.
MeSH terms
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Antineoplastic Agents, Phytogenic / administration & dosage*
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Antineoplastic Agents, Phytogenic / adverse effects
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Antineoplastic Agents, Phytogenic / pharmacokinetics
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Camptothecin / administration & dosage*
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Camptothecin / adverse effects
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Camptothecin / analogs & derivatives*
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Camptothecin / pharmacokinetics
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Drug Administration Schedule
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Female
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Granulocyte Colony-Stimulating Factor / administration & dosage
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Humans
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Irinotecan
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Kidney Failure, Chronic / therapy
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Leukopenia / chemically induced
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Lung Neoplasms / drug therapy*
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Lung Neoplasms / metabolism
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Lung Neoplasms / secondary
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Middle Aged
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Neoplasm Recurrence, Local / drug therapy*
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Neoplasm Recurrence, Local / metabolism
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Neutropenia / chemically induced
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Rectal Neoplasms / drug therapy*
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Rectal Neoplasms / metabolism
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Rectal Neoplasms / pathology
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Rectal Neoplasms / surgery
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Renal Dialysis*
Substances
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Antineoplastic Agents, Phytogenic
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Granulocyte Colony-Stimulating Factor
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Irinotecan
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Camptothecin