Abstract
Penicillin resistance is mainly confined to a limited number of Streptococcus pneumoniae serotypes. Given linkage between the capsular biosynthesis locus and two penicillin binding proteins, we tested whether capsule homology increases transformation rates of penicillin resistance. Transformation rates in homologous donor-recipient pairs were no higher than expected, falsifying this hypothesis.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Anti-Bacterial Agents / pharmacology
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Bacterial Capsules / genetics*
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Bacterial Proteins / genetics*
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Penicillin Resistance
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Penicillin-Binding Proteins / genetics*
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Penicillins / pharmacology
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Peptidyl Transferases / genetics*
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Serotyping
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Streptococcus pneumoniae / classification
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Streptococcus pneumoniae / drug effects
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Streptococcus pneumoniae / genetics*
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Transformation, Bacterial*
Substances
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Anti-Bacterial Agents
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Bacterial Proteins
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Penicillin-Binding Proteins
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Penicillins
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PBP 2x protein, Streptococcus
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PBP1a protein, Streptococcus pneumoniae
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Peptidyl Transferases