Abstract
The pharmacokinetics of oral doxycycline administered at 200 mg every 24 h were investigated in 17 patients recovering from severe Plasmodium falciparum malaria. The data suggest that the doses of doxycycline currently recommended (circa 3.5 mg/kg of body weight daily) may not be optimal.
Publication types
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Clinical Trial
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Randomized Controlled Trial
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Research Support, Non-U.S. Gov't
MeSH terms
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Administration, Oral
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Adolescent
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Adult
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Aged
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Animals
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Antimalarials / administration & dosage
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Antimalarials / pharmacokinetics*
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Antimalarials / therapeutic use
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Artemisinins / administration & dosage
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Artemisinins / therapeutic use
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Artesunate
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Doxycycline / administration & dosage
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Doxycycline / pharmacokinetics*
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Doxycycline / therapeutic use
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Drug Therapy, Combination
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Female
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Humans
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Malaria, Falciparum / drug therapy*
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Malaria, Falciparum / parasitology
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Male
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Middle Aged
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Plasmodium falciparum / drug effects
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Sesquiterpenes / administration & dosage
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Sesquiterpenes / therapeutic use
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Severity of Illness Index
Substances
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Antimalarials
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Artemisinins
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Sesquiterpenes
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Artesunate
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Doxycycline