Abstract
Class D beta-lactamase OXA-57 was identified in a range of isolates of Burkholderia pseudomallei and Burkholderia thailandensis. Comparative kinetic analyses of wild-type and mutant forms of B. pseudomallei OXA-57 are reported. Implications of these data for beta-lactam resistance and the proposed role of Ser-104 in beta-lactam hydrolysis are discussed.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Anti-Bacterial Agents / metabolism
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Anti-Bacterial Agents / pharmacology
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Burkholderia / drug effects
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Burkholderia / enzymology*
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Burkholderia pseudomallei / drug effects
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Burkholderia pseudomallei / enzymology*
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Humans
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Kinetics
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Molecular Sequence Data
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Mutation
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beta-Lactamases / chemistry
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beta-Lactamases / genetics
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beta-Lactamases / metabolism*
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beta-Lactams / metabolism
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beta-Lactams / pharmacology
Substances
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Anti-Bacterial Agents
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beta-Lactams
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beta-Lactamases