Abstract
The in vitro and in vivo antileishmanial and cytotoxic activities of thymol and structural derivatives in comparison to those of Glucantime were studied. The results showed here suggest that thymol and hemisynthetic derivatives have promising antileishmanial potential and could be considered as new lead structures in the search for novel antileishmanial drugs.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antiprotozoal Agents / chemistry
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Antiprotozoal Agents / pharmacology*
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Antiprotozoal Agents / therapeutic use
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Cricetinae
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Female
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Humans
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Leishmania / drug effects
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Leishmaniasis / drug therapy
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Leishmaniasis / parasitology
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Male
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Meglumine / pharmacology
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Meglumine / therapeutic use
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Meglumine Antimoniate
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Organometallic Compounds / pharmacology
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Organometallic Compounds / therapeutic use
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Parasitic Sensitivity Tests
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Structure-Activity Relationship
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Terpenes / chemistry
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Terpenes / pharmacology*
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Terpenes / therapeutic use
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Thymol / analogs & derivatives*
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Thymol / chemistry
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Thymol / pharmacology*
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Thymol / therapeutic use
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U937 Cells
Substances
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Antiprotozoal Agents
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Organometallic Compounds
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Terpenes
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Thymol
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Meglumine
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Meglumine Antimoniate