Direct injection chemotherapy in combination with transcatheter arterial embolization (TAE) was carried out in primary and secondary liver cancers. In this treatment, the anticancer agents dissolved in contrast media were directly injected into the tumor tissue with the echo-guided puncture needle after TAE. The dynamics of the injected drugs marked with non-ionic and water-soluble contrast media was followed up by the sequential CT studies, on which the contrast media was observed only in the tumor area in 18 out of 30 nodules from 2 to 8 weeks after the injection. The procedure is considered an effective drug delivery system to achieve a targeting chemotherapy in the liver cancers.