Fusarium verticillioides abscess of the nasal septum in an immunosuppressed child: case report and identification of the morphologically atypical fungal strain

Hans Jürgen Dornbusch; Walter Buzina; Richard C Summerbell; Cornelia Lass-Flörl; Herwig Lackner; Wolfgang Schwinger; Petra Sovinz; Christian Urban

doi:10.1128/JCM.43.4.1998-2001.2004

Fusarium verticillioides abscess of the nasal septum in an immunosuppressed child: case report and identification of the morphologically atypical fungal strain

J Clin Microbiol. 2005 Apr;43(4):1998-2001. doi: 10.1128/JCM.43.4.1998-2001.2004.

Authors

Hans Jürgen Dornbusch¹, Walter Buzina, Richard C Summerbell, Cornelia Lass-Flörl, Herwig Lackner, Wolfgang Schwinger, Petra Sovinz, Christian Urban

Affiliation

¹ Division of Pediatric Hematology/Oncology, Medical University, Graz, the Netherlands.

Abstract

Morphologically atypical Fusarium verticillioides causing a nasal abscess in a severely immunosuppressed child was successfully treated with repeated surgical intervention and liposomal amphotericin B, despite amphotericin B resistance in vitro. Definitive identification was achieved by sequencing the translation elongation factor alpha gene after ribosomal sequencing proved inadequate.

Publication types

Case Reports

MeSH terms

Abscess / drug therapy
Abscess / microbiology*
Abscess / surgery
Amphotericin B / therapeutic use
Antifungal Agents / pharmacology
Antifungal Agents / therapeutic use
Child
Fusarium / classification
Fusarium / drug effects
Fusarium / genetics
Fusarium / isolation & purification*
Humans
Immunocompromised Host*
Liposomes / therapeutic use
Male
Microbial Sensitivity Tests
Molecular Sequence Data
Mycoses / drug therapy
Mycoses / microbiology*
Mycoses / surgery
Nasal Septum / microbiology*
Sequence Analysis, DNA

Substances

Antifungal Agents
Liposomes
liposomal amphotericin B
Amphotericin B

Associated data

GENBANK/AY533376
GENBANK/AY611386