Statins and autoimmune diseases

Victor S Gurevich; Ora Shovman; Liat Slutzky; Pier Luigi Meroni; Yehuda Shoenfeld

doi:10.1016/j.autrev.2004.08.037

Statins and autoimmune diseases

Autoimmun Rev. 2005 Mar;4(3):123-9. doi: 10.1016/j.autrev.2004.08.037.

Authors

Victor S Gurevich¹, Ora Shovman, Liat Slutzky, Pier Luigi Meroni, Yehuda Shoenfeld

Affiliation

¹ Mechnicov's State Medical Academy, The Center of Atherosclerosis and Lipid Disorders, Tel-Hashomer, Israel.

PMID: 15823497
DOI: 10.1016/j.autrev.2004.08.037

Abstract

Inhibitors of 3-hydroxy-3methylglytaryl coenzyme A (HMG-CoA) reductase or statins are effective lipid lowering drugs widely used in cardiovascular disease. In the recent years, pleotropic effects of statins have been reported, which include anti-inflammatory and immunomodulatory properties. This review discusses the anti-inflammatory and immunomodulatory roles of statins and their possible use for the treatment of other inflammatory diseases or conditions with the involvement of the immune system.

Publication types

Review

MeSH terms

Animals
Anti-Inflammatory Agents / pharmacology*
Autoimmune Diseases / drug therapy*
Autoimmune Diseases / immunology
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors / pharmacology*
Macrophages / drug effects
T-Lymphocytes / drug effects

Substances

Anti-Inflammatory Agents
Hydroxymethylglutaryl-CoA Reductase Inhibitors