The multitude of targets for the immune system and drug therapy in the fungal cell wall

Leonardo Nimrichter; Marcio L Rodrigues; Elaine G Rodrigues; Luiz R Travassos

doi:10.1016/j.micinf.2005.03.002

The multitude of targets for the immune system and drug therapy in the fungal cell wall

Microbes Infect. 2005 Apr;7(4):789-98. doi: 10.1016/j.micinf.2005.03.002. Epub 2005 Mar 17.

Authors

Leonardo Nimrichter¹, Marcio L Rodrigues, Elaine G Rodrigues, Luiz R Travassos

Affiliation

¹ Laboratório de Estudos Integrados em Bioquímica Microbiana, Instituto de Microbiologia Professor Paulo de Góes, Universidade Federal do Rio de Janeiro, Cidade Universitária, CCS, Bloco I, Ilha do Fundão, Rio de Janeiro, RJ 21941590, Brazil.

PMID: 15823515
DOI: 10.1016/j.micinf.2005.03.002

Abstract

Recent studies on fungi revealed that several cytosolic and membrane components migrate to the cell wall together with secreted proteins and biosynthetic polysaccharides to build a dynamic immunoreactive structure. New aspects of fungal cell wall assembly and biosynthesis, focusing on the potential of glycolipids, melanin, heat-shock proteins, histone and surface antigens as targets of drugs and antifungal antibodies are discussed.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Antifungal Agents / pharmacology*
Antifungal Agents / therapeutic use
Cell Wall* / chemistry
Cell Wall* / drug effects
Cell Wall* / immunology
Fungal Proteins / drug effects
Fungal Proteins / immunology
Fungi / drug effects*
Fungi / pathogenicity
Humans
Mycoses / drug therapy*
Mycoses / immunology*
Mycoses / microbiology

Substances

Antifungal Agents
Fungal Proteins