Tomato spotted wilt virus transcriptase in vitro displays a preference for cap donors with multiple base complementarity to the viral template

Virology. 2005 Apr 25;335(1):122-30. doi: 10.1016/j.virol.2005.01.041.

Abstract

Transcription of segmented negative-strand RNA viruses is initiated by cap snatching: a host mRNA is cleaved generally at 10-20 nt from its 5' capped end and the resulting capped leader used to prime viral transcription. For Tomato spotted wilt virus (TSWV), type species of the plant-infecting Tospovirus genus within the Bunyaviridae, cap donors were previously shown to require a single base complementarity to the ultimate or penultimate viral template sequence. More recently, the occurrence in vitro of "re-snatching" of viral mRNAs, i.e., the use of viral mRNAs as cap donors, has been demonstrated for TSWV. To estimate the relative occurrence of re-snatching compared to snatching of host mRNAs, the use of cap donors with either single, double, or multiple complementarity to the viral template was analyzed in pair-wise competition in TSWV in vitro transcription assays. A strong preference was observed for multiple-basepairing donors.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Base Pairing*
  • Base Sequence
  • DNA Primers
  • DNA-Directed RNA Polymerases / metabolism*
  • Molecular Sequence Data
  • RNA Caps / metabolism*
  • RNA, Messenger / chemistry
  • RNA, Messenger / metabolism*
  • RNA, Viral / chemistry
  • RNA, Viral / genetics
  • RNA, Viral / metabolism
  • Rabbits
  • Solanum lycopersicum
  • Templates, Genetic
  • Tospovirus / enzymology*
  • Tospovirus / genetics
  • Tospovirus / metabolism
  • Transcription, Genetic*

Substances

  • DNA Primers
  • RNA Caps
  • RNA, Messenger
  • RNA, Viral
  • DNA-Directed RNA Polymerases