Does lesion size determine the success rate of photodynamic therapy for age-related macular degeneration?

Eye (Lond). 2006 Jan;20(1):43-5. doi: 10.1038/sj.eye.6701787.

Abstract

Photodynamic therapy (PDT) is a new evidence-based treatment modality available for choroidal neovascularisation (CNV) secondary to age-related macular degeneration (AMD). Eligibility for PDT is based on the morphological classification of the neovascular complex, the benefit being greater in classic with no occult lesions. Lesion size is also shown to be a predictive factor for treatment benefit. This retrospective case series looked at effect of initial and final lesion size on the visual outcome of patients with subfoveal classic with no occult CNV and found that increasing initial and final lesion size is associated with poorer visual outcome.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Female
  • Fluorescein Angiography
  • Follow-Up Studies
  • Humans
  • Logistic Models
  • Macular Degeneration / drug therapy*
  • Macular Degeneration / pathology*
  • Male
  • Middle Aged
  • Photochemotherapy*
  • Photosensitizing Agents / therapeutic use*
  • Retina / pathology*
  • Retrospective Studies
  • Signal Processing, Computer-Assisted
  • Treatment Outcome
  • Visual Acuity

Substances

  • Photosensitizing Agents