Abstract
We present an algorithm that explicitly utilizes the wavelength dependence of tissue optical properties for diffuse optical tomography. We have previously shown that the method gives superior separation of absorption and scattering. Here the technique is described and tested in detail, and optimum wavelength sets for a broad range of chromophore combinations are discovered and analyzed.
Publication types
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Evaluation Study
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Research Support, U.S. Gov't, P.H.S.
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Validation Study
MeSH terms
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Algorithms*
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Biomarkers, Tumor / metabolism
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Breast Neoplasms / metabolism
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Breast Neoplasms / pathology*
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Computer Simulation
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Female
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Hemoglobins / metabolism
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Humans
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Image Enhancement / methods*
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Image Interpretation, Computer-Assisted / methods*
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Models, Biological
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Pattern Recognition, Automated / methods*
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Reproducibility of Results
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Scattering, Radiation
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Sensitivity and Specificity
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Spectrophotometry / methods*
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Tomography, Optical / methods*
Substances
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Biomarkers, Tumor
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Hemoglobins