Primary structure, recombinant expression and homology modelling of human brain prolyl oligopeptidase, an important therapeutic target in the treatment of neuropsychiatric diseases

J Pept Sci. 2005 May;11(5):283-7. doi: 10.1002/psc.676.
No abstract available

Publication types

  • Comparative Study
  • Historical Article
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Brain / enzymology*
  • Central Nervous System Diseases / drug therapy
  • Central Nervous System Diseases / enzymology
  • Gene Expression
  • History, 20th Century
  • Humans
  • Mental Disorders / drug therapy
  • Mental Disorders / enzymology
  • Models, Molecular
  • Molecular Sequence Data
  • Peptides / chemistry
  • Peptides / history
  • Proline-Rich Protein Domains
  • Prolyl Oligopeptidases
  • Protein Conformation
  • Proteomics
  • Recombinant Proteins / chemistry
  • Recombinant Proteins / genetics
  • Recombinant Proteins / metabolism
  • Sequence Homology, Amino Acid
  • Serine Endopeptidases / chemistry*
  • Serine Endopeptidases / genetics
  • Serine Endopeptidases / metabolism
  • Swine

Substances

  • Peptides
  • Recombinant Proteins
  • Serine Endopeptidases
  • PREPL protein, human
  • Prolyl Oligopeptidases