Abstract
[reaction: see text] The synthesis and some properties of two novel DTPA-bisamides are reported. These derivatives were designed as enzyme-activated contrast agents (CA) for magnetic resonance imaging. Both derivatives bear tyramido or 5-hydroxytryptamido groups that could be oligomerized in situ in the presence of peroxidase/H(2)O(2) pair resulting in a net increase in longitudinal (R1) relaxivity.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Contrast Media* / chemical synthesis
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Contrast Media* / chemistry
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Gadolinium DTPA / chemistry
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Magnetic Resonance Imaging*
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Pentetic Acid / analogs & derivatives
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Pentetic Acid / chemical synthesis*
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Pentetic Acid / chemistry
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Peroxidases / metabolism*
Substances
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Contrast Media
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Pentetic Acid
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Peroxidases
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Gadolinium DTPA