Abstract
Bioassay-guided fractionation of boiled aqueous extracts from the whole plant of Phyllanthus niruri led to the isolation of 1-O-galloyl-6-O-luteoyl-alpha-d-glucose (1), with IC(50) values of 4.7 microg/mL against Babesia gibsoni and 1.4 microg/mL against Plasmodium falciparum in vitro. The known compounds beta-glucogallin (2), quercetin 3-O-beta-d-glucopyranosyl-(2-->1)-O-beta-d-xylopyranoside (3), beta-sitosterol, and gallic acid were also isolated. Structures of these compounds were elucidated on the basis of their chemical and spectroscopic data.
MeSH terms
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Animals
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Babesia / drug effects*
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Gallic Acid / analogs & derivatives*
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Gallic Acid / chemistry
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Gallic Acid / isolation & purification*
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Gallic Acid / pharmacology
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Gas Chromatography-Mass Spectrometry
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Glucose / analogs & derivatives*
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Glucose / chemistry
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Glucose / isolation & purification*
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Glucose / pharmacology
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Glucosides / chemistry
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Glucosides / isolation & purification*
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Glucosides / pharmacology
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Indonesia
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Inhibitory Concentration 50
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Phyllanthus / chemistry*
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Plants, Medicinal / chemistry*
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Plasmodium falciparum / drug effects*
Substances
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1-O-galloyl-6-O-luteoyl-alpha-D-glucose
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Glucosides
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Gallic Acid
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Glucose