Abstract
Ataxia severity, cerebellar hemispheric blood flow (CHBF), ascorbate free radical (AFR), superoxide dismutase protein, superoxide scavenging activity, and 8-hydroxy-2'-deoxyguanosine (8-OHdG) in cerebrospinal fluid (CSF) were compared before and after an 8-week course of repetitive transcranial magnetic stimulation (rTMS) in 20 patients with spinocerebellar degenerations (SCD). SCD patients showed higher AFR, 8-OHdG, and superoxide scavenging activity than 19 controls. In SCD patients, AFR and ataxia severity declined, and CHBF increased after rTMS. As the SCD patients showed negative correlations between ataxia severity and CHBF or superoxide scavenging activity, the therapeutic mechanism of rTMS may involve decreased oxidative stress and increased CHBF.
Publication types
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Clinical Trial
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Comparative Study
MeSH terms
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Adult
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Ascorbic Acid / cerebrospinal fluid
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Cerebrovascular Circulation / physiology
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Deoxyadenosines / cerebrospinal fluid
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Electric Stimulation Therapy* / methods
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Enzyme-Linked Immunosorbent Assay / methods
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Free Radical Scavengers / cerebrospinal fluid*
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Humans
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Middle Aged
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Oxidative Stress*
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Regional Blood Flow / physiology
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Severity of Illness Index
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Spinocerebellar Degenerations* / cerebrospinal fluid
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Spinocerebellar Degenerations* / classification
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Spinocerebellar Degenerations* / physiopathology
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Spinocerebellar Degenerations* / surgery
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Superoxide Dismutase / cerebrospinal fluid
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Time Factors
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Transcranial Magnetic Stimulation*
Substances
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8-hydroxy-2'-deoxyadenosine
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Deoxyadenosines
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Free Radical Scavengers
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Superoxide Dismutase
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Ascorbic Acid