NF-kappa B comes home

Immunity. 2005 Apr;22(4):401-2. doi: 10.1016/j.immuni.2005.04.002.

Abstract

NF-kappa B was discovered because of its binding to the Ig kappa locus intronic enhancer, but deletion of its binding site does not appear to affect V-to-J kappa rearrangement. New work by Verkoczy et al. in this issue of Immunity suggests that NF-kappa B regulates Ig kappa rearrangement after all, by activating RAG expression during receptor editing.

Publication types

  • Comment

MeSH terms

  • Animals
  • Enhancer Elements, Genetic
  • Homeodomain Proteins / metabolism
  • Immunoglobulin kappa-Chains / genetics
  • Immunoglobulin kappa-Chains / metabolism*
  • NF-kappa B / metabolism*

Substances

  • Homeodomain Proteins
  • Immunoglobulin kappa-Chains
  • NF-kappa B
  • RAG-1 protein