Abstract
Cryptococcus neoformans laccase expression during murine infection was investigated in lung tissue by immunohistochemistry and immunogold electron microscopy. Laccase was detected in the fungal cell cytoplasm, cell wall, and capsule in vivo. The amount of laccase found in different sites varied as a function of the time of infection.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Cryptococcosis / microbiology*
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Cryptococcus neoformans / enzymology*
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Cryptococcus neoformans / pathogenicity
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Cryptococcus neoformans / ultrastructure*
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Immunohistochemistry
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Laccase / metabolism*
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Lung / microbiology
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Lung Diseases, Fungal / microbiology*
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Mice
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Mice, Inbred BALB C
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Mice, Inbred C57BL
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Microscopy, Electron
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Virulence