Abstract
Previous work has suggested that in many neurological diseases genetic variability in the loci predisposing subjects to autosomal dominant disease contributes to the risk of sporadic disease. Here, using a population-based sample of dystonia cases, we show an association with the torsin A haplotype and sporadic idiopathic dystonia.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Alleles
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Dystonia / epidemiology
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Dystonia / genetics*
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Gene Frequency
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Genotype
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Haplotypes
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Humans
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Molecular Chaperones / genetics*
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Polymorphism, Single Nucleotide
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Population
Substances
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Molecular Chaperones
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TOR1A protein, human