We report three cases with advanced breast cancer were treated with a weekly dose of paclitaxel (TXL). Case 1: A 52-year-old female, diagnosed as having bilateral breast cancer with metastatis to right lung (S9) and sternum. A TXL weekly regimen was started (80 mg/m2 with the administration of the drug for three weeks followed by one week rest as one course). After twelve courses of treatment, bilateral breast masses significantly regressed with the disappearance of bilateral axillary and parasternal lymph node metastasis. The tumor marker was normalized, too. After two years and four months, the patient is still alive and continuing the weekly TXL regimen. Case 2: A 51-year-old female with right breast cancer and skin ulcer formation. After completing two courses of weekly TXL regimen, her mass was markedly reduced in size, which made it possible for her to undergo a modified mastectomy. Case 3: A 52-year-old female with breast cancer which invaded the skin. As a result of two courses of weekly TXL therapy, the tumor responded significantly and a modified mastectomy was conducted. The TXL weekly regimen seems to be very effective in regressing breast tumors and can be given safely in the outpatient setting with an extremely high utility profile as neoadjuvant chemotherapy as well.