Identification of a novel HLA-DQB1 allele, DQB1*0314, by sequence-based typing in the Korean population

H Gu; K Kimm; J-K Lee; B Oh

doi:10.1111/j.1399-0039.2005.00397.x

Identification of a novel HLA-DQB1 allele, DQB1*0314, by sequence-based typing in the Korean population

Tissue Antigens. 2005 May;65(5):503-4. doi: 10.1111/j.1399-0039.2005.00397.x.

Authors

H Gu¹, K Kimm, J-K Lee, B Oh

Affiliation

¹ National Genome Research Institute, National Institute of Health, 5 Nokbun-Dong, Eunpyung-Gu, Seoul 122-701, Korea.

PMID: 15853909
DOI: 10.1111/j.1399-0039.2005.00397.x

Abstract

The polymorphism of HLA class II genes is largely confined to the exon 2 region. Sequence analysis of exon 2 of the DQB1 gene revealed the novel polymorphism in the Korean population. The new DQB1 allele, DQB1*0314, was differed from DQB1*0304 only at codon 46 (GAG-->GGG), corresponding to non-synonymous amino acid change (Glu-->Gly).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alleles
Amino Acid Sequence
Amino Acid Substitution
Codon / genetics
Exons / genetics
Genes, MHC Class II*
HLA-DQ Antigens / chemistry
HLA-DQ Antigens / genetics*
HLA-DQ Antigens / isolation & purification
HLA-DQ beta-Chains
Humans
Korea
Membrane Glycoproteins
Molecular Sequence Data
Point Mutation
Sequence Alignment
Sequence Homology, Amino Acid

Substances

Codon
HLA-DQ Antigens
HLA-DQ beta-Chains
HLA-DQB1 antigen
Membrane Glycoproteins

Associated data

GENBANK/AY762968