Abstract
The infusion of aerial parts (EI) of Eleusine indica Gaertn (Poaceae) is used in Brazil against airway inflammatory processes like influenza and pneumonia. Pre-treatment with 400 mg/kg of crude extract inhibited 98% of lung neutrophil recruitment in mice exposed to aerosols of lipopolysaccharide (LPS) from Gram-negative bacteria, in a dose-dependent manner. At 400 microg/kg, schaftoside (6-C-beta-glucopyranosyl-8-C-alpha-arabinopyranosylapigenin) and vitexin (8-C-beta-glucopyranosylapigenin), isolated from EI, inhibited 62% and 80% of lung neutrophil influx, respectively. These results may justify the popular use of E. indica against airway inflammatory processes.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Anti-Inflammatory Agents, Non-Steroidal / administration & dosage
-
Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
-
Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
-
Dose-Response Relationship, Drug
-
Eleusine*
-
Flavones / administration & dosage
-
Flavones / pharmacology
-
Flavones / therapeutic use
-
Lipopolysaccharides
-
Lung Diseases / chemically induced
-
Lung Diseases / drug therapy*
-
Male
-
Mice
-
Mice, Inbred BALB C
-
Phytotherapy*
-
Plant Components, Aerial
-
Plant Extracts / administration & dosage
-
Plant Extracts / pharmacology*
-
Plant Extracts / therapeutic use
Substances
-
Anti-Inflammatory Agents, Non-Steroidal
-
Flavones
-
Lipopolysaccharides
-
Plant Extracts