A variant t(8;10;21) in a patient with pathological features mimicking atypical chronic myeloid leukemia

Jiyun Lee; William F Kern; Joan B Cain; John J Mulvihill; Shibo Li

doi:10.1016/j.cancergencyto.2004.10.002

A variant t(8;10;21) in a patient with pathological features mimicking atypical chronic myeloid leukemia

Cancer Genet Cytogenet. 2005 May;159(1):79-83. doi: 10.1016/j.cancergencyto.2004.10.002.

Authors

Jiyun Lee¹, William F Kern, Joan B Cain, John J Mulvihill, Shibo Li

Affiliation

¹ Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.

PMID: 15860363
DOI: 10.1016/j.cancergencyto.2004.10.002

Abstract

We report the case of an 11-year-old girl who was initially diagnosed with a chronic myeloproliferative disorder, possibly chronic myelogenous leukemia (CML), based on laboratory and blood and marrow morphological findings. The patient's high leukocyte count did not respond to hydroxyurea, a standard initial therapy for CML. Chromosomal analysis revealed that the patient did not have t(9;22), but a complex t(8;10;21)(q22;q24;q22), a variant of t(8;21). The treatment regime was switched to an acute myeloid leukemia (AML) protocol; the patient responded well and is now in remission. This case demonstrates again that routine clinical cytogenetic analysis plays an important role in the clinical diagnosis, guidance of treatment, and prognostication in hematological disorders.

Publication types

Case Reports

MeSH terms

Child
Chromosomes, Human, Pair 10 / genetics*
Chromosomes, Human, Pair 21 / genetics*
Chromosomes, Human, Pair 8 / genetics*
Cytogenetic Analysis
Female
Genetic Variation*
Humans
In Situ Hybridization, Fluorescence
Leukemia, Myelogenous, Chronic, BCR-ABL Positive / genetics*
Molecular Mimicry
Oncogene Proteins, Fusion / genetics
Translocation, Genetic*

Substances

Oncogene Proteins, Fusion