3,3-Bisaryloxindoles as mineralocorticoid receptor antagonists

David A Neel; Matthew L Brown; Peter A Lander; Timothy A Grese; Jean M Defauw; Robert A Doti; Todd Fields; Sally Ann Kelley; Stephon Smith; Karen M Zimmerman; Mitchell I Steinberg; Prabhakar K Jadhav

doi:10.1016/j.bmcl.2005.03.086

3,3-Bisaryloxindoles as mineralocorticoid receptor antagonists

Bioorg Med Chem Lett. 2005 May 16;15(10):2553-7. doi: 10.1016/j.bmcl.2005.03.086.

Authors

David A Neel¹, Matthew L Brown, Peter A Lander, Timothy A Grese, Jean M Defauw, Robert A Doti, Todd Fields, Sally Ann Kelley, Stephon Smith, Karen M Zimmerman, Mitchell I Steinberg, Prabhakar K Jadhav

Affiliation

¹ Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA. [email protected]

PMID: 15863315
DOI: 10.1016/j.bmcl.2005.03.086

Abstract

Syntheses and SAR studies of 3,3-bisaryloxindole analogues provided potent mineralocorticoid receptor (MR) antagonists that were selective over other steroid nuclear hormone receptors.

MeSH terms

Humans
Indoles / pharmacology*
Mineralocorticoid Receptor Antagonists*
Radioligand Assay

Substances

Indoles
Mineralocorticoid Receptor Antagonists