Identification of chemokine receptor CCR4 antagonist

Ashok V Purandare; Aiming Gao; Honghe Wan; John Somerville; Christine Burke; Carrie Seachord; Wayne Vaccaro; John Wityak; Michael A Poss

doi:10.1016/j.bmcl.2005.02.084

Identification of chemokine receptor CCR4 antagonist

Bioorg Med Chem Lett. 2005 May 16;15(10):2669-72. doi: 10.1016/j.bmcl.2005.02.084.

Authors

Ashok V Purandare¹, Aiming Gao, Honghe Wan, John Somerville, Christine Burke, Carrie Seachord, Wayne Vaccaro, John Wityak, Michael A Poss

Affiliation

¹ Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, NJ 08543, USA. [email protected]

PMID: 15863339
DOI: 10.1016/j.bmcl.2005.02.084

Abstract

The present study reports the identification and hits to leads optimization of chemokine receptor CCR4 antagonists. Compound 12 is a high affinity, non-cytotoxic antagonist of CCR4 that blocks the functional activity mediated by the receptor.

MeSH terms

Receptors, CCR4
Receptors, Chemokine / antagonists & inhibitors*
Receptors, Chemokine / physiology
Structure-Activity Relationship

Substances

Receptors, CCR4
Receptors, Chemokine