Abstract
The combination of reactive galactosyl iodide donors with electron-rich acceptor lipids provides highly stereoselective and efficient routes to alpha GalCer analogues. Using per-O-silylated donors, key intermediates can be obtained in a three-step, one-pot sequence providing useful constructs for analogue development.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Galactosylceramides / chemical synthesis*
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Galactosylceramides / chemistry
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Glycosides / chemistry*
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Iodides / chemistry*
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Molecular Structure
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Stereoisomerism
Substances
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Galactosylceramides
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Glycosides
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Iodides