Cytochrome c and tumor necrosis factor-alpha values in serum and cerebrospinal fluid of patients with influenza-associated encephalopathy

Pediatr Infect Dis J. 2005 May;24(5):467-70. doi: 10.1097/01.inf.0000160995.07461.b8.

Abstract

Cytochrome c and tumor necrosis factor-alpha concentrations were measured in serum and cerebrospinal fluid samples from 10 patients with influenza-associated encephalopathy. In the acute exacerbation phase, serum tumor necrosis factor-alpha and cytochrome c values were high in patients with a poor prognosis. In the convalescent phase, cerebrospinal fluid cytochrome c values increased remarkably in patients with subsequent brain atrophy.

Publication types

  • Comparative Study

MeSH terms

  • Biomarkers
  • Child
  • Child, Preschool
  • Cohort Studies
  • Cytochromes c' / blood*
  • Cytochromes c' / cerebrospinal fluid
  • Encephalitis, Viral / diagnosis*
  • Encephalitis, Viral / drug therapy
  • Encephalitis, Viral / mortality*
  • Female
  • Humans
  • Infant
  • Influenza, Human / diagnosis*
  • Influenza, Human / drug therapy
  • Influenza, Human / mortality
  • Male
  • Orthomyxoviridae / isolation & purification*
  • Probability
  • Prognosis
  • Risk Assessment
  • Sensitivity and Specificity
  • Severity of Illness Index
  • Statistics, Nonparametric
  • Survival Analysis
  • Tumor Necrosis Factor-alpha / analysis*
  • Tumor Necrosis Factor-alpha / cerebrospinal fluid

Substances

  • Biomarkers
  • Cytochromes c'
  • Tumor Necrosis Factor-alpha