Aryl-aryl coupling via directed lithiation and oxidation

Chem Commun (Camb). 2005 May 28:(20):2589-90. doi: 10.1039/b501939g. Epub 2005 Apr 12.

Abstract

Aryl lithium reagents formed by directed lithiation reactions undergo transmetallation with copper(I) salts to form organocuprates, which may be efficiently oxidized to yield ortho-substituted biaryls.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Hydrocarbons, Aromatic / chemical synthesis*
  • Lithium / chemistry*
  • Molecular Structure
  • Oxidation-Reduction

Substances

  • Hydrocarbons, Aromatic
  • Lithium