Anomalous swelling of lipid bilayer stacks is caused by softening of the bending modulus

Phys Rev E Stat Nonlin Soft Matter Phys. 2005 Apr;71(4 Pt 1):041904. doi: 10.1103/PhysRevE.71.041904. Epub 2005 Apr 7.

Abstract

Arrays of bilayers of the lipid dimyristoylphosphatidylcholine (DMPC) exhibit anomalous swelling as the temperature decreases from T=27 degrees C toward the main phase transition at T(M) =24 degrees C, within the fluid L(alpha) thermodynamic phase. Analysis of diffuse x-ray scattering data from oriented stacks of biological lipid bilayers now makes it possible to obtain the bending modulus K(C) and the bulk compressibility modulus B separately. We report results that show that the measured bending modulus K(C) for DMPC decreases by almost a factor of 2 between T=27 degrees C and the transition temperature at T(M) =24 degrees C, which is the same temperature range where the anomalous swelling occurs. We also report Monte Carlo simulations that show that the anomalous swelling can be fully accounted for by the measured decrease in K(C) with no changes in the van der Waals or hydration forces.

Publication types

  • Comparative Study
  • Evaluation Study
  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Validation Study

MeSH terms

  • Compressive Strength
  • Computer Simulation
  • Dimyristoylphosphatidylcholine / analysis
  • Dimyristoylphosphatidylcholine / chemistry*
  • Elasticity
  • Lipid Bilayers / chemistry*
  • Membrane Fluidity*
  • Models, Chemical*
  • Models, Molecular*
  • Molecular Conformation
  • Surface Properties
  • Temperature

Substances

  • Lipid Bilayers
  • Dimyristoylphosphatidylcholine