Staging intra-abdominal desmoid tumors in familial adenomatous polyposis: a search for a uniform approach to a troubling disease

Dis Colon Rectum. 2005 Aug;48(8):1528-34. doi: 10.1007/s10350-005-0018-8.

Abstract

Introduction: Desmoid tumors are a clinical problem in 12 to 15 percent of patients with familial adenomatous polyposis. There is no predictably effective treatment for intra-abdominal desmoid tumors, which sometimes cause significant complications by their effects on the ureters or bowel. The relative rarity and the clinical heterogeneity of intra-abdominal desmoid tumors make randomized studies difficult to do. In this article a staging system is proposed to make multi-institutional studies easier.

Methods: Intra-abdominal desmoid tumors can be staged according to their size, clinical presentation and growth pattern.

Conclusion: A way of staging intra-abdominal desmoid tumors is proposed to facilitate stratification by disease severity during collaborative studies of various treatments.

MeSH terms

  • Abdominal Neoplasms / pathology*
  • Abdominal Neoplasms / physiopathology
  • Abdominal Wall / pathology
  • Adenomatous Polyposis Coli / genetics
  • Adenomatous Polyposis Coli / pathology*
  • Clinical Protocols
  • Desmoid Tumors / pathology*
  • Desmoid Tumors / physiopathology
  • Genes, APC
  • Genotype
  • Humans
  • Mesentery / pathology
  • Mutation / genetics
  • Neoplasm Staging
  • Neoplasms, Multiple Primary / pathology*
  • Patient Care Planning
  • Peritoneal Neoplasms / pathology
  • Receptors, Estrogen / analysis
  • Receptors, Progesterone / analysis

Substances

  • Receptors, Estrogen
  • Receptors, Progesterone