Abstract
Human immunodeficiency virus (HIV) infection in peripheral blood mononuclear cells (PBMCs) might be influencing the development of wasting in the era of potent antiretroviral therapy. In a retrospective study of 57 subjects, HIV proviral DNA levels in PBMCs were higher in subjects whose body weight decreased by >5% one year after initiation of highly active antiretroviral therapy, compared with subjects whose body weight was stable or increased (median HIV proviral DNA load, 8.9 vs. 0.9 copies/10(6) PBMCs; P = .006).
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adult
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Antiretroviral Therapy, Highly Active*
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Antiviral Agents / therapeutic use
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Body Weight
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CD4 Lymphocyte Count
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Case-Control Studies
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DNA, Viral
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HIV Infections / complications*
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HIV Infections / drug therapy
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HIV Infections / virology*
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HIV Wasting Syndrome / etiology*
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HIV Wasting Syndrome / virology*
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Humans
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Middle Aged
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Monocytes / virology*
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Retrospective Studies
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Viral Load
Substances
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Antiviral Agents
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DNA, Viral