Simultaneous determination of bisphenol-A-diglycidyl ether, bisphenol-F-diglycidyl ether, and their derivatives in oil-in-water and aqueous-based canned foods by high-performance liquid chromatography with fluorescence detection

J Chromatogr A. 2005 May 6;1073(1-2):331-9. doi: 10.1016/j.chroma.2004.12.092.

Abstract

A gradient reversed-phase liquid chromatography with fluorescence detection method for simultaneous identification and quantification of bisphenol-A-diglycidyl ether (BADGE), bisphenol-F-diglycidyl ether (BFDGE), and their 10 derivatives in food matrixes was developed and validated for the analysis of oil-in-water- and aqueous-based foodstuffs. The method linearity range 0.016-10 ppm which are hundred-fold below and tenfold above the EU restriction at 1 ppm (mg/kg). The method detection limits range 0.72-4.20 ppb and the method quantitation limits range 2.40-14.85 ppb, respectively. The validation data indicate excellent precision, acceptable recovery, and good robustness, all supporting a good potential to further develop the method as a standard method for the determination of migrations from interior can coatings into foodstuffs.

Publication types

  • Research Support, Non-U.S. Gov't
  • Validation Study

MeSH terms

  • Benzhydryl Compounds
  • Calibration
  • Chromatography, High Pressure Liquid / methods*
  • Food Analysis / methods*
  • Phenols / analysis*
  • Reproducibility of Results
  • Sensitivity and Specificity
  • Spectrometry, Fluorescence / methods*

Substances

  • Benzhydryl Compounds
  • Phenols
  • bisphenol A