Solitary metachronous metastasis to the thyroid from renal clear cell carcinoma 19 years after nephrectomy: report of a case

Surg Today. 2005;35(6):483-7. doi: 10.1007/s00595-004-2953-8.

Abstract

We report a rare case of a solitary metachronous metastasis of renal clear cell carcinoma (RCC) presenting as a thyroid tumor 19 years after a nephrectomy. Our search of the English-language literature found only sporadic reports of late RCC metastases to the thyroid. Fine-needle aspiration biopsy of the thyroid tumor was not accompanied with thyroglobulin (Tg) staining, leading us to initially suspect a primary follicular thyroid carcinoma. The patient, a 77-year-old man, underwent a total thyroidectomy with modified neck dissection. Histological examination confirmed the tumor to be RCC metastasis, and immunohistochemical analysis revealed that both Tg and thyroid transcription factor-1 (TTF-1) were negative in the tumor cells. Thus, the possibility of late RCC metastasis to the thyroid should be considered, even in a patient with a remote history. Furthermore, TTF-1 is useful for identifying thyroid metastatic carcinomas.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Carcinoma, Renal Cell / secondary*
  • Humans
  • Immunohistochemistry
  • Kidney Neoplasms / mortality*
  • Lymph Node Excision
  • Male
  • Nuclear Proteins / metabolism
  • Thyroglobulin / metabolism
  • Thyroid Neoplasms / pathology
  • Thyroid Neoplasms / secondary*
  • Thyroid Neoplasms / surgery
  • Thyroid Nuclear Factor 1
  • Thyroidectomy
  • Time Factors
  • Transcription Factors / metabolism

Substances

  • NKX2-1 protein, human
  • Nuclear Proteins
  • Thyroid Nuclear Factor 1
  • Transcription Factors
  • Thyroglobulin