Abstract
Rinderpest virus (RPV) is a morbillivirus, related closely to the human pathogen Measles virus (MV). Although cell culture-adapted strains of RPV can infect many kinds of cell from different hosts, one such strain has previously been shown to have a detectable preference for cells expressing the MV receptor CD150 (SLAM), a protein found only on certain types of activated T cells, B cells and dendritic cells. Here, it is shown that the wild-type, virulent parent of the most common vaccine strain of RPV requires CD150 as a receptor, whilst the cell culture-adapted vaccine strain has acquired the ability to use heparan sulphate as an alternative receptor.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Adaptation, Physiological
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Animals
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Antigens, CD
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Cell Line
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Cricetinae
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Glycoproteins / genetics
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Glycoproteins / physiology*
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Humans
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Immunoglobulins / genetics
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Immunoglobulins / physiology*
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Mutation
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Receptors, Cell Surface
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Receptors, Virus / genetics
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Receptors, Virus / physiology*
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Recombination, Genetic
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Rinderpest virus / physiology*
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Signaling Lymphocytic Activation Molecule Family Member 1
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Virus Replication*
Substances
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Antigens, CD
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Glycoproteins
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Immunoglobulins
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Receptors, Cell Surface
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Receptors, Virus
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SLAMF1 protein, human
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Signaling Lymphocytic Activation Molecule Family Member 1