Current generation multidetector-row CT (MDCT) enables high-resolution, motion-free imaging of the heart within a single, short breath-hold. MDCT allows highly accurate and reproducible quantification of coronary artery calcium, a marker that has been used for the detection, exclusion and monitoring of coronary atherosclerosis. The exact role of coronary calcium measurements for cardiac risk stratification remains unclear to date. At contrast enhanced MDCT coronary angiography coronary arteries can be visualized with unprecedented detail. The accurate non-invasive assessment of the presence and degree of coronary artery stenosis appears within reach. With increasing accuracy MDCT enables non-invasive patency evaluation of coronary artery bypass grafts and coronary stents. The cross-sectional nature of contrast enhanced MDCT coronary angiography allows assessment of the vessel wall and may permit more accurate quantification of total atherosclerotic plaque burden than measuring calcified components alone. For a limited time, future technical improvement will be pursued mainly by accelerated gantry rotation speed and additional detector rows. However, novel concepts of CT image acquisition are already under investigation and may bring about yet another quantum leap for medical CT. This communication discusses potential approaches for the beneficial utilization of MDCT for the assessment of patients with known or suspected coronary heart disease.