Unbalanced 6p translocation as primary karyotypic anomaly in secondary acute nonlymphocytic leukemia

M Mancini; C Mecucci; M Cedrone; M B Rondinelli; M A Aloe-Spiriti; G Alimena

doi:10.1016/0165-4608(92)90242-z

Unbalanced 6p translocation as primary karyotypic anomaly in secondary acute nonlymphocytic leukemia

Cancer Genet Cytogenet. 1992 May;60(1):93-5. doi: 10.1016/0165-4608(92)90242-z.

Authors

M Mancini¹, C Mecucci, M Cedrone, M B Rondinelli, M A Aloe-Spiriti, G Alimena

Affiliation

¹ Hematology, Department of Human Biopathology, University of Rome La Sapienza, Italy.

PMID: 1591714
DOI: 10.1016/0165-4608(92)90242-z

Abstract

A case of acute nonlymphocytic leukemia after radiochemotherapy for Hodgkin's disease, with a rearrangement of 6p23 region, is described. This chromosome change, which has been previously reported in secondary leukemias or myelodysplastic syndromes, was an isolated karyotypic anomaly in our case, which strongly supports the nonrandom involvement of chromosome 6p in induced leukemias.

Publication types

Case Reports

MeSH terms

Adult
Antineoplastic Combined Chemotherapy Protocols / adverse effects
Chromosomes, Human, Pair 6*
Female
Hodgkin Disease / drug therapy*
Hodgkin Disease / radiotherapy*
Humans
Karyotyping
Leukemia, Myeloid, Acute / chemically induced
Leukemia, Myeloid, Acute / etiology
Leukemia, Myeloid, Acute / genetics*
Leukemia, Radiation-Induced / genetics
Translocation, Genetic*