Abstract
The effects of caspofungin combined with amphotericin B were investigated with Candida glabrata. Although in vitro experiments showed an indifferent interaction, the combination regimen was the only therapeutic approach yielding organ sterilization in a murine candidemia model.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amphotericin B / pharmacology
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Amphotericin B / therapeutic use*
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Animals
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Antifungal Agents / pharmacology
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Antifungal Agents / therapeutic use*
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Candida glabrata / drug effects*
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Candida glabrata / growth & development
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Candidiasis / drug therapy*
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Candidiasis / microbiology
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Caspofungin
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Colony Count, Microbial
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Drug Therapy, Combination
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Echinocandins
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Fungemia / drug therapy*
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Fungemia / microbiology
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Lipopeptides
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Male
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Mice
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Microbial Sensitivity Tests / methods
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Peptides, Cyclic / pharmacology
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Peptides, Cyclic / therapeutic use*
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Treatment Outcome
Substances
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Antifungal Agents
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Echinocandins
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Lipopeptides
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Peptides, Cyclic
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Amphotericin B
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Caspofungin