Abstract
Five new quinone derivatives, (R)-7-hydroxy-alpha-dunnione (1), (R)-8-hydroxy-alpha-dunnione (2), (R)-7,8-dihydroxy-alpha-dunnione (3), (R)-7-methoxy-6,8-dihydroxy-alpha-dunnione (4), and 1,7-dihydroxy-2-hydroxymethylanthraquinone (5), along with seven known compounds, were isolated from Chirita eburnea. All structures were elucidated by spectroscopic techniques (NMR, MS, UV, and IR). The EtOAc fraction of the EtOH extract and compounds 3 and 4 showed free radical (DPPH) scavenging activity, with IC50 values of 101.7 +/- 5.2 microg/mL, 124.82 +/- 8.4 microM, and 45.72 +/- 3.6 microM, respectively, compared with 86.91 +/-6.8 microM for ascorbate.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Algorithms
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Biphenyl Compounds
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Drugs, Chinese Herbal / chemistry
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Drugs, Chinese Herbal / isolation & purification*
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Drugs, Chinese Herbal / pharmacology
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Free Radical Scavengers / chemistry
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Free Radical Scavengers / isolation & purification*
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Free Radical Scavengers / pharmacology
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Magnoliopsida / chemistry*
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Picrates / pharmacology
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Plants, Medicinal / chemistry*
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Quinones / chemistry
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Quinones / isolation & purification*
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Quinones / pharmacology
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Stereoisomerism
Substances
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Biphenyl Compounds
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Drugs, Chinese Herbal
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Free Radical Scavengers
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Picrates
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Quinones
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1,1-diphenyl-2-picrylhydrazyl