Abstract
Botulinum toxins are metalloproteases that act inside nerve terminals and block neurotransmitter release via their activity directed specifically on SNARE proteins. This review summarizes data on botulinum toxin modes of binding, sites of action, and biochemical activities. Their use in cell biology and neuroscience is considered, as well as their therapeutic utilization in human diseases characterized by hyperfunction of cholinergic terminals.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Autonomic Nervous System Diseases / drug therapy
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Botulinum Toxins / pharmacokinetics
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Botulinum Toxins / pharmacology*
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Botulinum Toxins / therapeutic use
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Humans
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Neurons / drug effects*
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Neurotoxins / pharmacology*
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Neurotoxins / therapeutic use
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Protein Binding
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SNARE Proteins / drug effects
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Tetanus Toxin / pharmacokinetics
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Tetanus Toxin / pharmacology*
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Tetanus Toxin / therapeutic use
Substances
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Neurotoxins
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SNARE Proteins
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Tetanus Toxin
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Botulinum Toxins