Concomitant Ewing sarcoma and acute lymphoblastic leukemia in a 5-year-old girl

Pediatr Blood Cancer. 2005 Nov;45(6):846-9. doi: 10.1002/pbc.20265.

Abstract

Malignancies from the Ewing family of tumors and acute lymphoblastic leukemia (ALL) are not known to be associated with each other. A 5-year-old girl was incidentally found to suffer from acute lymphoblastic leukemia during bone marrow staging for Ewing sarcoma of the radius. The simultaneous presence of two distinct neoplasms was confirmed by RT-PCR, with EWS/FLI1 type 1 rearrangement in the bone tumor and TEL/AML1 rearrangement in the marrow. She was treated with chemotherapy, radiotherapy, and surgery and was in remission of both diseases 31 months after diagnosis.

Publication types

  • Case Reports

MeSH terms

  • Child, Preschool
  • Combined Modality Therapy
  • Core Binding Factor Alpha 2 Subunit
  • Disease-Free Survival
  • Female
  • Humans
  • Oncogene Proteins, Fusion
  • Polymerase Chain Reaction
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / complications*
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / diagnosis
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / therapy
  • Proto-Oncogene Protein c-fli-1
  • RNA-Binding Protein EWS
  • Sarcoma, Ewing / complications*
  • Sarcoma, Ewing / diagnosis
  • Sarcoma, Ewing / therapy
  • Translocation, Genetic

Substances

  • Core Binding Factor Alpha 2 Subunit
  • EWS-FLI fusion protein
  • Oncogene Proteins, Fusion
  • Proto-Oncogene Protein c-fli-1
  • RNA-Binding Protein EWS
  • TEL-AML1 fusion protein