Abstract
The cell division cycle involves nuclear and cytoplasmic events, namely organelle multiplication and distribution between the daughter cells. Until now, plastid and plant cell division have been considered as independent processes because they can be uncoupled. Here, down-regulation of AtCDT1a and AtCDT1b, members of the prereplication complex, is shown to alter both nuclear DNA replication and plastid division in Arabidopsis thaliana. These data constitute molecular evidence for relationships between the cell-cycle and plastid division. Moreover, the severe developmental defects observed in AtCDT1-RNA interference (RNAi) plants underline the importance of coordinated cell and organelle division for plant growth and morphogenesis.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Arabidopsis / cytology*
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Arabidopsis / genetics
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Arabidopsis / growth & development
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Arabidopsis / metabolism*
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Arabidopsis Proteins / genetics
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Arabidopsis Proteins / metabolism*
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Bromodeoxyuridine
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Carotenoids / analysis
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Cell Cycle
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Cell Cycle Proteins / genetics
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Cell Cycle Proteins / metabolism*
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Cell Division
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Cell Nucleus / metabolism
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Chlorophyll / analysis
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Gene Silencing
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Plant Leaves / cytology
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Plant Leaves / genetics
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Plant Leaves / metabolism
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Plastids / metabolism*
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Protein Binding
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Protein Transport
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Transgenes / genetics
Substances
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ARC6 protein, Arabidopsis
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Arabidopsis Proteins
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CDT1a protein, Arabidopsis
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CDT1b protein, Arabidopsis
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Cell Cycle Proteins
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Chlorophyll
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Carotenoids
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Bromodeoxyuridine