Abstract
A 24-year old primaparous female at 20 weeks gestation presented acutely with cerebellar symptoms. Magnetic resonance imaging brain showed evidence of a cerebellar vermis lesion. This was diagnosed as medulloblastoma on histopathological analysis. She underwent surgical debulking and radiotherapy. Interestingly, the lesion recurred 4 years later on her second pregnancy. She underwent further surgical debulking and adjuvant chemotherapy. We believe this is the first reported description of recurrent medulloblastoma in successive pregnancies. A brief discussion on this disease and its management in pregnancy setting is also presented.
MeSH terms
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Adult
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use
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Cerebellar Neoplasms / diagnosis*
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Cerebellar Neoplasms / drug therapy
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Cerebellar Neoplasms / surgery
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Chemotherapy, Adjuvant
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Cyclophosphamide / therapeutic use
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Doxorubicin / therapeutic use
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Etoposide / therapeutic use
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Female
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Humans
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Ifosfamide / therapeutic use
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Medulloblastoma / diagnosis*
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Medulloblastoma / drug therapy
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Medulloblastoma / surgery
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Neoplasm Recurrence, Local / diagnosis*
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Neoplasm Recurrence, Local / drug therapy
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Neoplasm Recurrence, Local / surgery
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Pregnancy
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Pregnancy Complications, Neoplastic / diagnosis*
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Pregnancy Complications, Neoplastic / therapy
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Treatment Outcome
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Vincristine / therapeutic use
Substances
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Vincristine
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Etoposide
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Doxorubicin
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Cyclophosphamide
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Ifosfamide