Treatment of human disseminated strongyloidiasis with a parenteral veterinary formulation of ivermectin

Francisco M Marty; Colleen M Lowry; Martin Rodriguez; Danny A Milner; Walter S Pieciak; Anushua Sinha; Lawrence Fleckenstein; Lindsey R Baden

doi:10.1086/430827

Treatment of human disseminated strongyloidiasis with a parenteral veterinary formulation of ivermectin

Clin Infect Dis. 2005 Jul 1;41(1):e5-8. doi: 10.1086/430827. Epub 2005 May 11.

Authors

Francisco M Marty¹, Colleen M Lowry, Martin Rodriguez, Danny A Milner, Walter S Pieciak, Anushua Sinha, Lawrence Fleckenstein, Lindsey R Baden

Affiliation

¹ Division of Infectious Diseases, Brigham and Women's Hospital, Boston, MA 02115, USA. [email protected]

PMID: 15937753
DOI: 10.1086/430827

Abstract

There are no parenteral antihelminthic drugs licensed for use in humans. We report the successful treatment of disseminated strongyloidiasis with a parenteral veterinary formulation of ivermectin in a patient presenting with severe malabsorption and paralytic ileus. To our knowledge, ivermectin levels are reported for the first time in this situation.

Publication types

Case Reports

MeSH terms

Animals
Antiparasitic Agents / administration & dosage*
Antiparasitic Agents / pharmacokinetics
Antiparasitic Agents / therapeutic use*
Biopsy
Duodenum / parasitology
Duodenum / pathology
Feces / parasitology
Female
Humans
Injections, Subcutaneous
Ivermectin / administration & dosage*
Ivermectin / pharmacokinetics
Ivermectin / therapeutic use*
Male
Middle Aged
Strongyloides stercoralis / drug effects*
Strongyloides stercoralis / isolation & purification
Strongyloidiasis / drug therapy*
Strongyloidiasis / parasitology
Strongyloidiasis / pathology
Treatment Outcome
Veterinary Medicine / methods

Substances

Antiparasitic Agents
Ivermectin