Abstract
The guideline of Japanese Society of Hypertension in 2004 was opened in the early January in 2005. This recommends that blood pressure of the elderly people with hypertension should be lower as well as that of the young subjects. However, unfortunately, this does not mention how much lower blood pressure of the elderly hypertensive patients with renal insufficiency is. Our group has proposed the combination therapy with a low dose of more than 2 antihypertensive drugs to reduce blood pressure of these subjects in order to avoid adverse effects of antihypertensive agents. As the combination therapy, drugs with inhibition of the renin-angiotensin system such as ACE inhibitor or angiotensin receptor blocker and a calcium antagonist or diuretics are suggested.
MeSH terms
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Aged
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Angiotensin II Type 1 Receptor Blockers / administration & dosage
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Angiotensin II Type 1 Receptor Blockers / pharmacology
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Angiotensin-Converting Enzyme Inhibitors / administration & dosage
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Angiotensin-Converting Enzyme Inhibitors / pharmacology
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Antihypertensive Agents / administration & dosage*
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Antihypertensive Agents / adverse effects
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Calcium Channel Blockers / administration & dosage
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Cardiovascular Diseases / etiology
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Depression, Chemical
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Diuretics / administration & dosage
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Drug Therapy, Combination
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Glomerular Filtration Rate
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Humans
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Hypertension / complications*
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Hypertension / drug therapy*
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Kidney Diseases / complications*
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Kidney Diseases / physiopathology
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Practice Guidelines as Topic
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Renin-Angiotensin System / drug effects
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Risk Factors
Substances
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Angiotensin II Type 1 Receptor Blockers
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Angiotensin-Converting Enzyme Inhibitors
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Antihypertensive Agents
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Calcium Channel Blockers
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Diuretics