1-Amino-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid as a Tic mimetic: application in the synthesis of potent human melanocortin-4 receptor selective agonists

Bioorg Med Chem Lett. 2005 Jul 15;15(14):3430-3. doi: 10.1016/j.bmcl.2005.05.012.

Affiliation

¹ Department of Medicinal Chemistry, Merck Research Laboratories, Rahway, NJ 07065-0900, USA. [email protected]

PMID: 15951175
DOI: 10.1016/j.bmcl.2005.05.012

Abstract

The discovery of 1-amino-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid analogs as potent human melanocortin-4 selective agonists is described.

MeSH terms

Carboxylic Acids / pharmacology*
Humans
Molecular Conformation
Molecular Mimicry
Protein Binding / drug effects
Receptor, Melanocortin, Type 4 / agonists*
Receptor, Melanocortin, Type 4 / metabolism
Structure-Activity Relationship
Tetrahydroisoquinolines / chemistry*
Tetrahydronaphthalenes / pharmacology*

Substances

Carboxylic Acids
MC4R protein, human
Receptor, Melanocortin, Type 4
Tetrahydroisoquinolines
Tetrahydronaphthalenes
1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid